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. 2018 Dec 7;9:2891. doi: 10.3389/fimmu.2018.02891

Figure 6.

Figure 6

Analysis of splenic CD8+ cells from young and old mice collected at acute phase and stimulated ex-vivo by PMA. Intracellular cytokines transport blockers IMB were included during stimulation. Response of CD8+ T cells observed in young mice infected with B. microti, N40 or both was comparable to respective infected old mice except IL-21 producing cells numbers were higher in young infected mice. Each bar represents the mean ± s.d. (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).