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. 2018 Dec 13;10:404. doi: 10.3389/fnagi.2018.00404

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Copyright © 2018 Wang, Khosrowabadi, Ng, Hong, Chong, Wang, Chen, Hilal, Venketasubramanian, Wong, Chen, Ikram and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distinct functional connectome network topological changes in participants with mild and moderate CIND. Top: Compared to NCI, moderate CIND group had reduced nodal degree centrality and efficiency in the default-mode, salience, and somatomotor networks. Bottom: Compared to NCI, mild CIND group had reduced nodal degree centrality in the control network. At each row, compared to group B, a significant increase in group A is highlighted in orange and a significant decrease in group A is highlighted in blue (p < 0.01). There was no significant difference in nodal-wise metrics between moderate CIND and mild CIND. DN-B_Temp, default mode network part B, temporal region; SVAN-A_INS, salience/ventral attention network part A, insula; SMN-B_Cent, somatomotor network part B, central; CN-A_Temp, control network part A, temporal region.