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. 2018 Dec 13;9:1440. doi: 10.3389/fphar.2018.01440

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Copyright © 2018 Lyu, Zhou, Wang, Lv, Wang, Pan, Wang, Fan, Gao, Feng and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Network pharmacology analysis to identify key upstream regulators in aGVHD. (A) aGVHD related molecules. A total of 400 genes were collected by integrating GVHD related genes in GeneCards and IPA databases. (B) Key regulators in aGVHD. Top 20 upstream regulators are marked in green, the top 6 upstream regulators including TNF, IL-6, IFN-γ, APOE, STAT3, CD3 are highlighted in blue.