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. 2018 Dec 13;9:1440. doi: 10.3389/fphar.2018.01440

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Copyright © 2018 Lyu, Zhou, Wang, Lv, Wang, Pan, Wang, Fan, Gao, Feng and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of top upstream modulators of predicted XBJ and Danshen targets in aGVHD. (A) The network relationship of predicted XBJ targets in aGVHD and their top six upstream modulators. The six top upstream regulators are TNF, IL-6, IFN-γ, IL-1, RELA, and IL-1B. (B) The network relationship of predicted Danshen targets in aGVHD and their top six upstream modulators (HMOX1, IFN-γ, TNF, RELA, IL-1β, and IL-6).