Table 2.
NcRNAs involved in the inflammatory activation of microglia in AIS.
| NcRNAs | Targets | Mechanisms | Inflammatory activation of microglia | Reference(s) |
|---|---|---|---|---|
| miR-424 | CCND1, CDC25A, and CDK6 | Regulate cell cycle | Inhibit | Zhao et al.60 |
| miR-377 | VEGF and EGR2 | – | Promote | Fan et al.51 |
| miR-689, miR-124, and miR-155 | – | – | Promote | Freilich et al.58 |
| miR-771 and miR-145 | – | – | Inhibit | Freilich et al.58 |
| lncRNA SNHG14 | PLA2G4A | Sponge miR-145-5p | Promote | Qi et al.61 |
| lncRNA Gm4419 | IκB, NF-κB | Increase the expression of IL-1β, IL-6 and TNF-α | Promote | Wen et al.33 |
| lncRNA H19 | HDAC1 | – | Promote | Wang et al.62 |
AIS: acute ischemic stroke, ncRNA, non-coding RNA; miRNA, microRNA; lncRNA, long non-coding RNA; CCND1, cyclin D1; CDC25A, cell division cycle 25 homolog A; CDK6, cyclin-dependent kinase 6; VEGF, vascular endothelial growth factor; EGR2, growth response protein 2; PLA2G4A, cytosolic phospholipase A2; HDAC1, histone deacetylase 1.