Table 2.
Signaling Pathways related to Pericyte Functions in Stroke.
| Signaling pathways | Stroke types | Functions | References |
|---|---|---|---|
| PDGF-BB/PDGFRβ | Ischemic stroke | Neuroprotection, angiogenesis and vascular remodeling, pericyte recruitment, scar formation and fibrosis regulation | 11,12,21,25,65,66 |
| Hemorrhagic stroke | BBB maintenance | 11,12,20,25 | |
| Notch | CADASIL | Regulation of pericyte survival and angiogenesis | 55,43,44 |
| Neonatal intraventricular hemorrhage | Pericyte recruitment, Pericyte–endothelium interaction, BBB maintenance | 55,67 | |
| Canonical Wnt/β-catenin | Ischemic stroke | BBB maintenance | 18 |
| Hemorrhagic stroke | Angiogenesis regulation | 18 | |
| TGF-β/TGFβR2 | Neonatal Intraventricular hemorrhage | Maintenance of vascular stability/BBB integrity | 67,68 |
| Ischemic stroke | Angiogenesis regulation and vessel stabilization | 69,70 | |
| VEGF-A/VEGFR2 | Ischemic stroke and hypoxia | Angiogenesis induction and tight junction stabilization | 71–73 |
| Ang/Tie2 | Ischemic stroke | ECM protein deposition and BBB protection | 10,19 |
| aPKC-CBP | Ischemic stroke | Vascular remodeling and motor recovery | 62 |
aPKC: atypical protein kinase C; BBB: blood–brain barrier; CADASIL: cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy; CBP: Creb binding protein; ECM: extracellular matrix; PDGF: platelet-derived growth factor; PDGFRβ: beta-type platelet-derived growth factor receptor; TGF: transforming growth factor; VEGF: vascular endothelial growth factor; VEGFR: vascular endothelial growth factor receptor.