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. 2018 Jun 27;27(12):1731–1743. doi: 10.1177/0963689718779364

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© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Effects of APN on HT22 cells. HT22 cells were incubated with 100 µmol/L APN for 4 h. (a) Cell morphology, viability, and LDH release were measured 24 h later. Cells were photographed under an inverted/phase-contrast microscope. Viability and LDH release are expressed as optical density (OD) and absorbance, respectively. (b) Effects of 100 µmol/L APN on the expression and phosphorylation of JAK2 and STAT3 were evaluated using western blot analysis. β-actin was used as a loading control, and the levels of total JAK2, p-JAK2 (Y1007/Y1008), total STAT3, and p-STAT3 (Y705) were normalized to control. n = 6. *P < 0.05, compared with control.