Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Jun 27;27(12):1731–1743. doi: 10.1177/0963689718779364

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

PMC Copyright notice

Figure 8. — JAK2/STAT3 mediated protection of APN against OGD. OGD damages mitochondrial structure and function, which induces oxidative stress and apoptosis. APN promotes the phosphorylated activation of JAK2/STAT3 signaling, and may further upregulate Bcl-2 and decrease cleaved-caspase-3 expression, which improve mitochondrial membrane integrity, maintain MMP, attenuate ROS generation, and increase anti-oxidative enzymes. Taken together, APN attenuates mitochondrial vulnerability through the JAK2/STAT3 pathway, performing an anti-oxidative and anti-apoptotic effect in HT22 neuronal cells subjected to OGD.