Table II.
Genotypic and allelic frequency of IL-6 promoter polymorphism (-174) and (-572) in patients with CD and healthy controls
| Variable | Genotype and allele | Celiac patient (n = 105) | Healthy control (n = 106) | CI | OR | P-value |
|---|---|---|---|---|---|---|
| rs1800795 | GG | 47 (44.8%) | 61 (57.5%) | Ref. | Ref. | Ref. |
| CC | 11 (10.5%) | 5 (4.7%) | 0.372–1.157 | 0.656 | 0.145 | |
| CG | 47 (44.8%) | 40 (37.7%) | 0.114–1.077 | 0.35 | 0.06 | |
| G | 141 (67.1%) | 162 (76.4%) | Ref. | Ref. | Ref. | |
| C | 69 (32.9%) | 50 (23.6%) | 0.411–0.968 | 0.631 | 0.034 | |
| rs1800796 | GG | 38 (36.2%) | 12 (11.3%) | Ref. | Ref. | Ref. |
| CG | 60 (57.1%) | 90 (84.9%) | 0.451–7.260 | 1.810 | 0.403 | |
| CC | 7 (6.7%) | 4 (3.8%) | 2.297– 9.823 | 4.750 | < 0.001 | |
| G | 136 (64.8%) | 114 (53.8%) | Ref. | Ref. | Ref. | |
| C | 74 (35.2%) | 98 (46.2%) | 1.068–2.336 | 1.580 | 0.022 |