Table 2.
Main studies evaluating the correlation between PASAT performance and MRI measures in multiple sclerosis
| Author/year | Number of patients | MRI measures | Main results |
|---|---|---|---|
| Morgen et al., 2006 [7] | 19 RRMS | T1 | Correlation with bilateral prefrontal cortex, precentral gyrus, superior parietal cortex and right cerebellum |
| Dineen et al., 2009 [25] | 37 MS | DTI (TBSS) | Correlation with fractional anisotropy in corpus callosum, parieto-occipital radiations of the forceps major, left cingulum, right inferior longitudinal fasciculus, left superior longitudinal fasciculus, and bilateral arcuate fasciculi |
| Sepulcre et al., 2009 [29] | 54 MS | T2 (VLSM) | Correlation with bilateral parieto-frontal, centrum semiovale, temporo-occipital white matter, internal capsule, right pontomesencephalic tegmentum, right cerebellar peduncle, and right anterior cingulate |
| Van Hecke et al., 2010 [26] | 20 MS | DTI | Correlation with fractional anisotropy in left inferior longitudinal fasciculus, forceps minor, internal and external capsule, corpus callosum, left cingulum, superior longitudinal fasciculus, and corona radiate |
| Nocentini et al., 2012 [9] | 18 MS | T1 | No significant correlations |
| Yu et al., 2012 [27] | 37 RRMS | DTI | Correlation with reduced fractional anisotropy in sagittal striatum, posterior thalamic radiation, and external capsule |
| Sbardella et al., 2013 [8] | 36 RRMS | T1 and DTI | Correlation with orbitofrontal cortex, and white matter tracts including the corpus callosum, internal capsule, posterior thalamic radiations, and cerebral peduncles |
| D’haeseleer et al., 2013 [30] | 18 MS | Arterial spin labelling | Correlation between PASAT performance and cerebral blood flow in the left centrum semiovale |
| Baltruschat et al., 2015 [31] | 17 RRMS | T1 and fMRI | No significant correlation between PASAT performance and functional connectivity in the MS group |
| Riccitelli et al., 2017 [10] | 177 RRMS | T1 (VBM) and DTI (TBSS) | Correlation with atrophy of the bilateral thalamus, caudate and putamen, right anterior cingulate, right superior frontal gyrus, and right precentral, left superior temporal, and right fusiform gyri. Correlation with reduced fractional anisotropy and increased mean diffusivity in several white matter tracts |
| Present study | 242 MS | T1 (VBM) and FLAIR (VLSM) | Correlation with bilateral precuneus and posterior cingulate, bilateral caudate and putamen, and bilateral anterior cerebellum |
RRMS relapsing-remitting multiple sclerosis, MS multiple sclerosis, DTI diffusion tensor imaging, TBSS tract-based spatial statistics, VLSM voxel-based lesion symptom mapping; fMRI functional magnetic resonance imaging, VBM voxel-based morphometry, FLAIR fluid-attenuated inversion recovery