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. 2018 Dec 20;16:103. doi: 10.1186/s12951-018-0429-z

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — The effect of siGRP78 modified exosomes on the metastasis of Sorafenib resistant cancer cells. a The orthotopic metastasis model showed the tumor metastasis in liver by different treatments (Control, Sorafenib, Exo-scramble siRNA + Sora and Exo-siGRP78 + Sora). b Statistic analysis showed the number of tumor nodes in liver of mice (*P < 0.05, versus Sorafenib treatment)