Table 2.

Summary of Maximum-Grade Adverse Events per Patient (Start to Completion of Radiotherapy)

Adverse Event	CCRT (n=40)		RT Alone (n=25)		Wilcoxon P Value
	Grade	No. (%)	Grade	No. (%)
Aspiration	1	0	1	0	.07
	2	3 (7.5)	2	0
	3	2 (5.0)	3	0
	4	0	4	0
Constipation	1	14 (35.0)	1	2 (8.0)	.005
	2	4 (10.0)	2	0
	3	1 (2.5)	3	1 (4.0)
	4	0	4	0
Cough	1	4 (10.0)	1	3 (12.0)	.96
	2	3 (7.5)	2	2 (8.0)
	3	1 (2.5)	3	0
	4	0	4	0
Dermatitis	1	2 (5.0)	1	2 (8.0)	.11
	2	35 (87.5)	2	22 (88.0)
	3	3 (7.5)	3	0
	4	0	4	0
Diarrhea	1	9 (22.5)	1	4 (16.0)	.26
	2	0	2	0
	3	2 (5)	3	0
	4	0	4	0
Dysphagia	1	3 (7.5)	1	1 (4.0)	.92
	2	5 (12.5)	2	5 (20.0)
	3	2 (5.0)	3	0
	4	0	4	0
Lung infection	1	0	1	0	.07
	2	1 (2.5)	2	0
	3	4 (10.0)	3	0
	4	0	4	0
Mucositis	1	9 (22.5)	1	8 (32.0)	<.001
	2	24 (60.0)	2	8 (32.0)
	3	6 (15.0)	3	0
	4	0	4	0
Nausea	1	12 (30.0)	1	4 (16.0)	<.001
	2	13 (32.5)	2	2 (8.0)
	3	8 (20.0)	3	1 (4.0)
	4	0	4	0
Odynophagia	1	5 (12.5)	1	6 (24.0)	<.001
	2	29 (72.5)	2	9 (36.0)
	3	5 (12.5)	3	0
	4	0	4	0
Oral pain	1	1 (2.5)	1	6 (24.0)	.30
	2	13 (32.5)	2	3 (12.0)
	3	2 (5.0)	3	0
	4	0	4	0
Rash acneiform	1	3 (7.5)	1	0	.02
	2	4 (10.0)	2	0
	3	0	3	0
	4	1 (2.5)	4	0
Sinus crusting	1	0	1	0	.03
	2	0	2	3 (12.0)
	3	0	3	0
	4	0	4	0
Somnolence	1	0	1	0	.27
	2	1 (2.5)	2	0
	3	1 (2.5)	3	0
	4	0	4	0
Thromboembolic event	1	0	1	0	.08
	2	0	2	0
	3	0	3	2 (8.0)
	4	0	4	0
Xerostomia	1	13 (32.5)	1	6 (24.0)	.01
	2	19 (47.5)	2	6 (24.0)
	3	0	3	0
	4	0	4	0
Overall maximum grade	1	0	1	0	.002
adverse event	2	20 (50.0)	2	22 (88.0)
	3	18 (45.0)	3	3 (12.0)
	4	2 (5.0)	4	0

Abbreviations: CCRT, concurrent chemoradiotherapy; RT, radiotherapy.