Table 2.

Effect of LXR ligand on genes involved in lipid metabolism in PPARc-deficient mouse liver.

Gene	PparγWT				Pparγ∆H
	OB/OB		ob/ob		OB/OB		ob/ob
	Control	T0901317	Control	T0901317	Control	T0901317	Control	T0901317
PPARc	1.0 ± 0.03	0.96 ± 0.04	1.0 ± 0.04	0.98 ± 0.02	N.D.	N.D.	1.0 ± 0.13	1.1 ± 0.04
LXRa	1.0 ± 0.04	0.67 ± 0.01**	1.0 ± 0.03	0.52 ± 0.01***	1.0 ± 0.07	0.84 ± 0.02*	1.0 ± 0.05	0.54 ± 0.02**
ChREBP	1.0 ± 0.07	1.3 ± 0.05*	1.0 ± 0.03	1.0 ± 0.01	1.0 ± 0.02	1.6 ± 0.01***	1.0 ± 0.06	0.95 ± 0.04
SREBP-1c	1.0 ± 0.02	2.0 ± 0.10*	1.0 ± 0.02	1.0 ± 0.03	1.0 ± 0.03	2.5 ± 0.21*	1.0 ± 0.03	1.6 ± 0.05*
Fas	1.0 ± 0.05	11 ± 0.21***	1.0 ± 0.09	3.1 ± 0.14**	1.0 ± 0.16	10 ± 0.10***	1.0 ± 0.07	5.3 ± 0.17***
Scd1	1.0 ± 0.02	8.2 ± 0.49***	1.0 ± 0.06	2.7 ± 0.05***	1.0 ± 0.02	8.4 ± 0.45***	1.0 ± 0.04	3.8 ± 0.11***
Gpat	1.0 ± 0.05	3.6 ± 0.07***	1.0 ± 0.03	2.4 ± 0.04***	1.0 ± 0.03	4.0 ± 0.03***	1.0 ± 0.10	4.3 ± 0.05***
Lpk	1.0 ± 0.04	0.66 ± 0.01**	1.0 ± 0.05	0.89 ± 0.04	1.0 ± 0.07	1.4 ± 0.05***	1.0 ± 0.09	1.0 ± 0.03
Ap2	1.0 ± 0.01	1.7 ± 0.33*	1.0 ± 0.06	1.6 ± 0.04**	1.0 ± 0.02	1.7 ± 0.14**	1.0 ± 0.06	1.4 ± 0.04**
CD36	1.0 ± 0.08	5.9 ± 0.05***	1.0 ± 0.04	0.9 ± 0.10	1.0 ± 0.03	6.1 ± 0.14***	1.0 ± 0.00	1.2 ± 0.01***

Each group is from 3 mice. Pparγ^WT, wild type PPARγ mice; Pparγ^∆H, hepatocyte-specific PPARγ null mice ChREBP, carbohydrate response element-binding protein; SREBP-1c, sterol regulatory element-binding protein-1c; Fas, fatty acid synthase; Scd1, stearoyl-CoA desaturase 1; Lpk, liver-type pyruvate kinase; Gpat, glycerol-3-phosphate acyltransferase; Ap2, adipocyte fatty acid-binding protein; CD36, class B scavenger receptor. N.D., not detected. Values are mean ± SE.

^*p < 0.05.

^**p < 0.01.

^***p < 0.001 versus control without T0901317.