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. Author manuscript; available in PMC: 2018 Dec 20.
Published in final edited form as: J Comp Neurol. 2017 Mar 23;525(9):2192–2201. doi: 10.1002/cne.24197

Fig. 3. PD motor subtype by drug interaction on connectivity between putamen and motor network.

Fig. 3

(A) Effective connectivity between left posterior putamen seed (cyan) and motor network areas during right hand finger tapping was affected by levodopa differently in the TD and PIGD subtypes. Maps reflect voxel-wise P = 0.005, cluster-corrected α = 0.05. (B) The magnitude and direction of connectivity changes ON minus OFF levodopa for both motor subtypes are displayed for five regions showing a subtype by medication effect. Overall, connectivity with the left posterior putamen increased in TD ON vs. OFF, but was relatively unchanged or decreased in PIGD ON vs. OFF. Error bars represent +/− one standard error of the mean.