Table 5.
Analysis by CDR3 length spectratype of PaLN cells from NOD and NOR micea
| TRBV gene | Vβ family |
Jβ family |
Total of expanded peaksc |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Jβ1–1 | Jβ1–2 | Jβ1–5 | Jβ1–6 | Jβ2–1 | Jβ2–2 | Jβ2–3 | Jβ2–4 | Jβ2–5 | Jβ2–7 | |||
| TRBV5 | Vβ1 | 1b | 1 | 1 | 0 | 3 | ||||||
| TRBV1 | Vβ2 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 2 | ||
| TRBV2 | Vp4 | 2 | 1 | 1 | 0 | 0 | 4 | |||||
| TRBV19 | Vβ6 | 0 | 0 | 1 | 1 | 2 | ||||||
| TRBV13-3 | Vβ8.1 | 0 | 1 | 0 | 1 | 2 | ||||||
| TRBV13-2 | Vβ8.2 | 1 | 3 | 0 | 0 | 3 | 1 | 3 | 0 | 0 | 2 | 13 |
| TRBV16 | Vβ11 | 3 | 0 | 2 | 0 | 0 | 1 | 6 | ||||
| TRBV15 | Vβ12 | 0 | 1 | 0 | 1 | 1 | 1 | 4 | ||||
| Total | 6 | 3 | 0 | 1 | 6 | 1 | 8 | 1 | 4 | 6 | 36 | |
a
Only the TCR Vβ chains used more frequently by public clonotypes are shown.
b
Number of peaks within that specific Vβ-Jβ spectratype that are significantly expanded in PaLN of the NOD mice compared with NOR mice.
c
Total number of peaks within the entire spectratype for that specific TCR Vβ chain that are significantly expanded in the NOD mice compared with NOR mice.
10-wk-old NOD mice, n=10–17; 10-wk-old NOR mice, n=5–10.