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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: J Cell Physiol. 2018 Mar 25;233(9):7217–7225. doi: 10.1002/jcp.26552

FIGURE 1.

FIGURE 1

AT1aRs are central for regulation of ENaC activity in the CD by Angiotensin II. (a) Representative continuous current traces from cell-attached patches monitoring ENaC activity in the control and during application of 500 nM Ang II (shown with a bar on the top) in a split-opened CD from WT (upper trace) and AT1aR −/− (bottom trace) mice. The patches were held at a test potential of Vh = − Vp = − 60 mV. Inward currents are downward. Dashed lines indicate the respective current state with a c denoting the closed state. (b) Summary graph of ENaC Po changes in response to Ang II from paired patch clamp experiments in WT and AT1aR −/− mice similar to that shown in Figure 1a.*significant increase versus WT control. (c) Summary graph of ENaC Po changes in response to stimulation of Mas receptors with 500 nM Ang 1–7 in split-opened CDs from Wild type mice