FIGURE 2.

ENaC activity is reduced in AT_1aR −/− mice. Representative current traces of ENaC activity in split-opened CDs isolated from Wild type (left column) and AT_1aR −/− (right column) mice kept on control (0.32% Na⁺, top row) and low (<0.01% Na⁺, bottom row) salt intake for 1 week. Dashed lines indicate the respective current state with o_i indicating the number of simultaneously opened channels; c denotes the closed non-conducting state