FIGURE 4.

Inhibition of AT1R with losartan reduces ENaC activity on low and control salt intake. Summary graphs of averaged total ENaC activity, fNP_o (a); ENaC open probability, P_o (b); and number of active channels fN (c) in Wild type mice kept on low (<0.01% Na⁺), control (0.32% Na⁺), and high (~2% Na⁺) salt diets for one week in the absence (light gray) and presence (dark gray) of concomitant treatment with AT₁R antagonist losartan (10 mg/kgBW) in drinking water, respectively. At least four different animals were tested for each condition. *significant decrease versus respective untreated conditions