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. Author manuscript; available in PMC: 2019 Dec 18.
Published in final edited form as: Immunity. 2018 Dec 11;49(6):1090–1102.e7. doi: 10.1016/j.immuni.2018.10.009

Figure 1. CD4+ T cells control persistent Se-Tomato infection.

Figure 1.

(A) Survival of wild-type (n =13), TCRα-deficient (n = 12), or MHCII-deficient, CD4+ T cell-deficient (n = 11) 129 mice infected intragastrically with 108 Se-Tomato bacteria. Survival curves were compared using the Log rank (Mantel-Cox) test to determine significance. (B) Mean CFU (± geometric S.D.) in the spleens of wild-type (n = 7), TCRα-deficient (n = 9), or MHCII-deficient, CD4+ T cell-deficient mice (n = 8), 30 days after intragastric infection with 108 Se-Tomato bacteria. CFU values were log-transformed and columns were compared using one-way ANOVA, with Tukey’s multiple comparisons post-test (*** p ≤ 0.0002) and derived of two independent experiments. (C)Spleen CFU (± geometric S.D.) from 129 mice infected intragastrically with 108 SeTomato bacteria, rested for 60 days, injected intraperitoneally with 0.8 mg of CD4 (n = 15), CD8 (n = 4), IFN-γ (n = 9), or isotype control (n = 25) antibodies twice 3 days apart, before CFU measurement seven days later. Spleen CFU values were log-transformed and analyzed using one-way ANOVA, with Tukey’s multiple comparisons post-test (*** p < 0.001, **** p < 0.0001, n.s. = not significant) to evaluate the significance between groups.