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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2018 Sep 8;103(1):229–240. doi: 10.1016/j.ijrobp.2018.09.001

FIGURE 2. Association between the Post-mdSBRT Immunophenotypic Responses in Circulating CD8+ T-cell Subpopulations and Clinical Outcomes.

FIGURE 2.

Forest plots demonstrating the association between changes in the relative percentage of circulating CD8+ T-cell subpopulations and clinical outcomes including (A) death, (B) any disease progression, local or distant, (C) new distant metastasis, and (D) local progression. All plots shown convey the results of immunophenotypic changes that occurred between baseline and day 14 after metastasis-directed stereotactic body radiation therapy. Hazard ratios are per 1 unit increase in the variable. TN (CD8+CCR7+CD45RA+), Naïve T-cell; TEF (CD8+CCR7-CD45RA+), Effector T-cell; TCM (CD8+CCR7+CD45RA-), Central Memory T-cell; TEM (CD8+CCR7-CD45RA-), Effector Memory T-cell; TTR (CD8+PD-1+CD11ahigh), Tumor-Reactive T-cell; CI, Confidence Interval.