Figure 4.

Schematic representation of FSHR and LHCGR expression in the ovarian granulosa cells during the menstrual cycle. (A) The domination of FSHR expression is noticeable during the first half of the cycle, while the second half of the cycle is dominated by the LHCGR expression. However, small expression of the LHCGR receptor is present during the early follicular stages. (B) During the simultaneous expression of LHCGR and FSHR both receptors form heterodimers. (C) Co-expression of liganded LHCGR and non-liganded FSHR results in either decreased cAMP production or prolonged Ca²⁺ release in LHCGR.