Table 3. Comparison of genotype and allele frequencies of the CTSS SNPs loci between the study group and the control group.

SNPs	Study group (n=315)	Control group (n=220)	Crude OR (95% CI)	P-value	Adjusted OR (95% CI)	P-value
rs774320676
Genotype
AA	167	155	Ref
AT	100	55	1.688 (1.116–2.555)	0.009	1.244 (1.049–1.453)	0.012
TT	48	10	4.455 (2.088–9.749)	<0.001	1.596 (1.315–1.802)	<0.001
Alleles
A	434	365	Ref
T	196	75	2.198 (1.610–3.002)	<0.001	1.332 (1.200–1.460)	<0.001
rs768437857
Genotype
GG	161	115	Ref
GT	115	84	0.978 (0.664–1.439)	0.906	0.991 (0.740–1.162)	0.981
TT	39	21	1.327 (0.714–2.475)	0.340	1.114 (0.865–1.356)	0.419
Alleles
G	437	314	Ref
T	193	126	1.101 (0.835–1.451)	0.482	1.040 (0.927–1.157)	0.525
rs928508030
Genotype
AA	163	143	Ref
AG	140	73	1.682 (1.154–2.455)	0.005	1.234 (1.061–1.25)	0.006
GG	9 (3.67%)	2 (1.37%)	2.764 (0.537–19.046)	0.184	1.408 (0.878–1.748)	0.149
Alleles
A	466	359	Ref
G	164	81	1.560 (1.144–2.129)	0.004	1.185 (1.055–1.314)	0.002
rs2275235
Genotype
CC	179	121	Ref
CT	121	84	0.979 (0.671–1.429)	0.909	0.991 (0.847–1.153)	0.983
TT	15	15	0.60 (0.301–1.533)	0.312	0.840 (0.527–1.172)	0.414
Alleles
C	479	326	Ref
T	151	114	0.901 (0.674–1.206)	0.469	0.958 (0.842–1.078)	0.515

Factors such as age, sex, drinking, smoking, BMI, and other factors were adjusted by logistic regression in ‘ORa’.