Table 2. In vitro activity of the remaining Pathogen Box against T.b. brucei.

Cpd no.	ID	T. brucei brucei IC50 (μM)			Selectivity index c
		Duffy et al. a	This study	HeLa IC50 (μM)
35	MMV021013	3.51	0.83	>25	30
36	MMV024311	5.15	2.2	8.9	4.0
37	MMV153413	2.99	11	>25	2.2
38	MMV461553	ND b	11	>25	2.2
39	MMV676477	ND	0.59	2.6	4.4
40	MMV676411	3.22	0.76	8.4	11
41	MMV676512	2.87	1.1	5.1	4.6
42	MMV687273	2.28	2.3	15	6.5
43	MMV676409	ND	2.9	>25	8.6
44	MMV687703	ND	4.2	22	5.2
45	MMV687765	ND	5.1	>25	4.9
46	MMV687812	ND	0.87	4.8	5.5
47	MMV688844	ND	29	>25	0.8
48	MMV675968	2.07	1.2	>25	21
49	MMV687776	ND	1.2	10	8.3
50	MMV688417	6.10	4.3	>25	5.8
51	MMV024035	2.72	1.0	7.5	7.5
52	MMV006901	3.36	4.7	>25	5.3
53	MMV010576	ND	0.33	>25	76
54	MMV019189	4.68	1.0	6.6	6.6
55	MMV020391	ND	6.5	12	1.8
56	MMV022029	2.38	0.22	13	59
57	MMV023233	3.29	1.2	5.4	4.5
58	MMV028694	2.39	1.5	>25	17
59	MMV1030799	ND	7.1	>25	3.5
60	MMV002817	ND	2.0	>25	13
61	MMV688761	3.49	11	>25	2.3
62	MMV637229	ND	3.5	>25	7.1
63	MMV272144	4.12	ND	ND
64	MMV495543	5.45	ND	ND
65	MMV687248	1.05	ND	ND
66	MMV687807	0.66	ND	ND
67	MMV022478	1.45	ND	ND
68	MMV026490	6.02	ND	ND
69	MMV688768	1.50	ND	ND
	Pentamidine		0.0031
	Emetine			0.4

^aData reported in ref. 17.

^bND = not determined.

^cSelectivity index calculated as IC₅₀(HeLa)/IC₅₀(T.bb).