Table 2.
Therapeutic status in β-thalassemia patients under treatment with bosentan
| Variables | Cases | ||
|---|---|---|---|
| 1 | 2 | 3 | |
| Bosentan dose (mg/day) | 125 | 125×2 | 125 |
| Duration of bosentan (months) | 48 | 12 | 8 |
| Sildenafil before bosentan | Yes | No | No |
| Sildenafil dose before bosentan (mg/day) | 200 | – | – |
| Duration of sildenafil before bosentan (years) | 2 | – | – |
| Sildenafil after bosentan | Yes | – | – |
| Sildenafil dose after bosentan (mg/day) | 100 | – | – |
| Type of iron chelator before bosentan | DFP + DFO | DFP + DFX | DFX |
| Dose of DFO chelator before bosentan (mg/day) | 2,000 | – | – |
| Duration of DFO chelator before bosentan (years) | 14 | – | – |
| Dose of DFX chelator before bosentan (mg/day) | – | 1,500 | 1,500 |
| Duration of DFX chelator before bosentan (years) | – | 2 | 3 |
| Dose of DFP chelator before bosentan (mg/day) | 3,000 | 1,500 | – |
| Duration of DFP chelator before bosentan (years) | 14 | 4 | – |
| Type of iron chelator after bosentan | DFP + DFO | DFP + DFX | DFP |
| Dose of DFO chelator after bosentan (mg/day) | 2,000 | – | – |
| Dose of DFX chelator after bosentan (mg/day) | – | 1,500 | – |
| Dose of DFP chelator after bosentan (mg/day) | 2,000 | 1,500 | 1,500 |
| Age starting iron chelators (years) | 14 | 34 | 1 |
| Time receiving iron chelators (total) (years) | 32 | 10 | 10 |
| Hydroxyurea (mg/kg) | – | 5–20 | 5–20 |
| Time using hydroxyurea (years) | – | 17 | 19 |
Abbreviations: DFO, desferrioxamine; DFP, deferiprone; DFX, deferasirox.