Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Dec 17;11:13–23. doi: 10.2147/CMAR.S184781

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 Ma and Sun. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

PMC Copyright notice

OTUB2 knockdown can mimic, while OTUB2 overexpression can antagonize, the effects of miR-29a-3p on PTC cell growth, proliferation, and invasion.

Notes: (A) OTUB2 was successfully knocked down by specific siRNAs. OTUB2 knockdown suppressed cell growth (B), proliferation, and invasion (C), in PTC cells. (D) OTUB2 ectopic expression rescued the level of OTUB2 in PTC cells transfected by miR-29a-3p mimics. OTUB2 ectopic expression released the inhibitory effects of miR-29a-3p on growth (E), proliferation, and invasion (F), in PTC cells. *^,#P<0.05, **^,##P<0.01. # and ## stand for the statistical difference between miR-29a-3p mimics group and miR-29a-3p mimics+OTUB2 group. * and ** stand for the statistical difference between miR-29a-3p mimics group and control mimics group.

Abbreviations: NC, negative control; PTC, papillary thyroid carcinoma; siRNA, small interfering RNA.