Depicted are (A) representative histopathologic pictures and (B) polymorphonuclear neutrophil (PMN) infiltration index of lung tissue sections from mice treated with LPS. Data are shown for WT mice administered saline at time 0 (WT, n = 4), WT mice administered LPS at time 0 (WT+LPS, n = 4), Grail KO mice administered saline at time 0 (Grail KO, n = 4), and Grail KO mice administered LPS at time 0 (Grail KO+LPS, n = 4). The data are presented as mean ± SEM. A one-way ANOVA with a Newman-Keuls post hoc test was used to evaluate statistical significance. *P < 0.05, LPS versus without LPS; #P < 0.05, Grail KO+LPS versus WT+LPS. Original magnification, ×400.