Table 2. Patients’ characteristics and outcomes of UC.
| Demographics/characteristics | UC (n = 1242) |
PSC-UC (n = 37) |
UC alone (n = 1205) |
p |
|---|---|---|---|---|
| Sex, male, n (%) | 678 (54.6) | 26 (70.3) | 652 (54.1) | 0.052 a |
| Median age at UC diagnosis (range) | 31 (0–87) | 27 (4–77) | 31 (0–87) | 0.392 b |
| Extent of UC, n (%) | ||||
| Proctitis | 218 (17.6) | 2 (5.4) | 216 (17.9) | 0.005 a |
| Left-sided | 277 (22.3) | 0 (0.0) | 277 (23.0) | < 0.001 a |
| Right-sided | 58 (4.7) | 6 (16.2) | 52 (4.3) | 0.003 a |
| Pancolitis | 500 (40.3) | 25 (67.6) | 475 (39.4) | < 0.001 a |
| Undefined/Unknown | 189 (15.2) | 4 (10.8) | 185 (15.4) | 0.641a |
| Medications, n (%) | ||||
| 5-ASA | 918 (73.9) | 26 (70.3) | 892 (74.0) | 0.608 a |
| Corticosteroids | 618 (49.8) | 13 (35.1) | 605 (50.2) | 0.071 a |
| Immunomodulator | 239 (19.2) | 4 (10.8) | 235 (19.5) | 0.287 a |
| Immunosuppressor | 186 (15.0) | 3 (8.1) | 183 (15.2) | 0.348 a |
| Anti-TNF agent | 147 (11.8) | 2 (5.4) | 145 (12.1) | 0.303 a |
| Colectomy, n (%) | 152 (12.2) | 1 (2.7) | 151 (12.6) | 0.076a |
| Colorectal cancer, n (%) | 17 (1.4) | 2 (5.4) | 15 (1.3) | 0.089 a |
| Cholangiocarcinoma, n (%) | 5 (4.0) | 4 (10.8) | 1 (0.1) | < 0.001 a |
| Median survival from diagnosis of UC, years (95% CI) | Undefined | Undefined | Undefined | < 0.001 c |
| 5-year survival rate from diagnosis of UC (%) | 99.3 | 96.2 | 99.4 | |
| 10-year survival rate from diagnosis of UC (%) | 98.8 | 76.9 | 99.4 | |
| UC flare cumulative incidence/person-years | 0.29 | 0.06 | 0.29 | < 0.001 d |
Abbreviations: PSC, primary sclerosing cholangitis; UC, ulcerative colitis; 95% CI, 95% Confidence interval
a p values were calculated using the Pearson χ2 test or Fisher exact test.
b p values were calculated using the Mann Whitney U test.
c p values were calculated using the log-rank test.
d p values were calculated using the person-years method.