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. 2018 Dec 20;13(12):e0206986. doi: 10.1371/journal.pone.0206986

Fig 6. Effects of SAK3 on monoamine releases in the hippocampus of APPNL-GF KI mice.

Fig 6

(A, C, E) Time zero indicates the point immediately after SAK3 oral administration. NA, DA, and 5-HT levels in the dialysate were analyzed every 16 min in the hippocampal CA1 region of APPNL-GF KI mice (n = 7 per group). Error bars represent the SEM. (B, D, F) NA, DA, and 5-HT levels following SAK3 (0.5 mg/kg, p.o.) administration were calculated with the AUC (n = 7 per group). **p < 0.01 vs. saline-treated mice. Error bars represent the SEM. APP: amyloid precursor protein, NA: noradrenaline, DA: dopamine, 5-HT: serotonin, AUC: area under the receiver operator characteristic curve.