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. 2018 Nov 21;19(11):1039–1056. doi: 10.1080/15384047.2018.1480279

Figure 8.

Figure 8.

TPM1 was down-regulated in bladder urothelial carcinoma. (A) Volcano plot, R package was used to analyze genes expressed differentially in bladder urothelial carcinoma after analyzing miRNAs expression profiles from 18 paired tissues of TCGA; (B) Heat map. R package showed the expression of the differentially expressed mRNAs. TPM1 was one of the low expressed genes. (C) RT-qPCR demonstrated that TPM1 was low expressed in bladder urothelial carcinoma tissues after comparing 45 tumor tissues with 45 adjacent tissues; (D) RT-qPCR revealed that TPM1 expression in 29 high-grade bladder urothelial cancer tissues was lower than that in 16 low-grade bladder urothelial cancer tissues; (E) RT-qPCR demonstrated that TPM1 production in 20 muscular invasive bladder cancer tissues was lower than that in 25 non-muscle invasive bladder cancer tissues; (F) RT-qPCR showed that TPM1 expression in 10 metastatic bladder cancer tissues was lower than that in 35 non-metastasis bladder cancer tissues; (G) RT-qPCR showed the expression of TPM1 in different BC cell line and normal cell line. **P < 0.01, compared with adjacent tissues, low grade bladder urothelial cancer, non-invasive bladder cancer or non-metastasis bladder cancer. Each RT-qPCR was repeated three times.