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Changes in CA-125 levels before and after apatinib therapy. The CA-125 levels continuously increased from 28U/mL (Dec. 2015) to 2288 U/mL (Sep. 2016) before apatinib treatment. Apatinib plus epirubicin (solid arrows) began in Sep. 2016. Following initiation of this therapy, CA-125 levels dramatically decreased to 269 U/mL (Mar. 2017). Then, Apatinib monotherapy was used as maintenance therapy (open arrows), CA-125 levels come into a stable level.
