Figure 2.

Whole genome sequencing of primary, and recurrent tumors. Circos plots summarizing somatic genomic variants in the primary tumor (A) and recurrent tumor (B). Each track, from the outside in represent: the VAF of each somatic SNV and indel (green VAF < 0.5, black VAF> 0.5; range 0.0 – 1.0); somatic log2 copy number (green gains, red losses; range −1.0 – 2.0); somatic BAF as blue lines (range 0.0 – 0.5); regions of LOH (blue blocks); and structural variations including translocations (red) and inversions (blue). SNV: single nucleotide variant; indel: small insertion or deletion; VAF: variant allele frequency; BAF: B-allele frequency, i.e., the somatic VAF, of germline heterozygous variants; LOH: loss of heterozygosity.