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. 2018 Dec 20;8:18000. doi: 10.1038/s41598-018-36125-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Endomorphin-1 slows the desensitization of ASIC3. (a) Top, representative current trace of an ASIC3 expressing oocyte conditioned with pH 7.0 (grey bars) and activated with pH 6.5 (black bars). Individual peptides of mix 1.2 (M1.2) were applied as indicated by the blue bars with a concentration of 20 μM each: endomorphin-1 (EM-1), leu-enkephalin (L-Enk), met-enkephalin (M-Enk), long proCART(55–59) (CART) and angiotensin I/II(1–5) (AT1–5). Bottom, scatter plot showing ratios of I to I_control. Bars show the mean and error bars the SD. (b) Scatter plot showing ratios of τ to τ_control. **p < 0.01 (paired Student’s t-test).