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. 2018 Dec 20;8:18007. doi: 10.1038/s41598-018-36703-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Vaccination with gH1-Qbeta elicits a poly-functional influenza-specific cytokine response. Distribution of positive cytokine responses from subjects vaccinated with (A,C) non-adjuvanted gH1-Qbeta (n = 37), (A,C) adjuvanted gH1-Qbeta (n = 43) and (B) trivalent influenza vaccine (n = 10). PBMCs were cultured with (A,B) peptide pools covering the gH1 antigen sequence, and (C) peptide pools covering the Qbeta sequence. Levels of the indicated cytokines were measured in the cell culture supernatants after eight days incubation. The size of the charts is proportional to the magnitude of the response (number of positive responses in all subjects for that visit is indicated for each chart; maximum of 150 for TIV, 555 for non-adjuvanted gH1-Qbeta, and 645 for adjuvanted gH1-Qbeta). Labels “Pre”, “Post1” and “Post2”, refer to Day 0, Day 21 and Day 42 post primary vaccination respectively.