Figure 6.
Robustness of GEM reconstruction for Hi-C data of human chromosome 8 (9) (5 kbp resolution). For all GEM reconstructions, we used a threshold ξ = 1 and a normalization factor Nc = 103. (A) A comparison of the contact probabilities of the reconstructed GEM with those of a GEM obtained by performing the minimization only on the top 90, 50, and 10% experimental contacts. (B) 2D histograms corresponding to the matrices shown in (A). We give the Pearson correlation coefficients. The thresholding quantiles are represented by vertical dashed lines. (C) A comparison of the GEMs reconstructed from a decreasing fraction of the experimental contacts with the original GEM. LSE1/2 is the Euclidean distance between contact probabilities divided by (N + 1). (D) Average contact probability as a function of the contour length for GEMs reconstructed from a decreasing fraction of the experimental contacts. To see this figure in color, go online.