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. 2018 Dec 14;9:1465. doi: 10.3389/fphar.2018.01465

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Copyright © 2018 Liang, Zheng, Wu, Li, Saw, Chen, Xu, Yao and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Cell viability of the macrophages incubated with the siCCL-18 loaded NPs at various concentrations for 48 h. (B) The mRNA level of CCL-18 in the macrophages treated by Lipo/siCCL-18 complexes (Lipo/siCCL-18), negative control siRNA loaded NP-180 (NP-180/siNC), and siCCL-18 loaded NP-180 (NP-180/siCCL-18). (C) Optical images of MDA-MB-231 cells incubated with the conditioned medium from the macrophages that treated with Lipo/siCCL-18, NP-180/siNC, and NP-180/siCCL-18 at a siRNA concentration of 400 nM. ^∗∗∗P < 0.001.