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. 2018 Dec 14;9:2954. doi: 10.3389/fimmu.2018.02954

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Copyright © 2018 Maseda, Banerjee, Johnson, Washington, Kim, Lau and Crofford.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EP4 deficient CD4⁺ T effector cells have severely blunted colitogenic potential due to impaired proliferative capacity. (A) Weight loss in Rag1^−/− mice that received transfer of Teff cells from EP4^fl/fl (EP4^WT) or CD4^Cre × EP4^fl/fl (EP4^ΔCD4) donor mice. (B) Colon pathology scores from both cohorts. Flow cytometry analysis of the (C) mLN and (D) cLP CD4⁺ populations at the end of the experiment (week 10), indicating intracellular expression of RORγt and FoxP3 in summarized results from 4 experiments. (E) Colon images detailing lamina propria T cell infiltrates in both groups, with magnified inserts on the right-hand side. Blue = DAPI, Gray = CD3ε, Green = RORγt, and Red = FoxP3. **P < 0.01 using in a one-way ANOVA with Welch's correction.