Table 2.
Cytotoxicity data of selected metallacycles against a panel of human cancer cells.
| Compound | IC50 (hrs of incubation)/Type of cells (IC50 of ref. compound) | IC50 (hrs of incubation)/Type of cells (IC50 of ref. compound) | References |
|---|---|---|---|
| A1 | 3.60 ± 0.21 μM (24 h)/HeLa (0.81 ± 0.08/CDDP) | Zhou et al., 2018a | |
| A2 | 1.76 ± 0.14 μM (24 h) HeLa (0.81 ± 0.08/CDDP) | 14.2 μM (24 h)/A2780cis (12.9/CDDP) | Zhou et al., 2018a |
| 3 | 2.11 ± 0.17 μM (24 h) HeLa (0.81 ± 0.08/CDDP) | 18.1 μM (24 h)/A2780cis (12.9/CDDP) | Zhou et al., 2018a |
| 4 | 6.41 ± 0.38 μM (24 h) HeLa (0.81 ± 0.08/CDDP) | Zhou et al., 2018a | |
| 3 + light | 0.37 μM (*+24 h)/HeLa | 0.76 μM (*+24 h)/A2780cis (12.9/CDDP) | Zhou et al., 2018a |
| 4 + light | 0.95 μM (*+24 h)/HeLa | Zhou et al., 2018a | |
| BODIPY + light | 4.88 μM (*+24 h)/HeLa | 6.09 μM (*+24 h)/A2780cis (12.9/CDDP) | Zhou et al., 2018a |
| 5a | 4.96 ± 0.17 μM (48 h)/U87 (6.06 ± 0.12/CDDP) | 16.71 ± 0.33 μM (48 h)/WI-38 (77.25 ± 7.28/CDDP) | Gupta et al., 2017 |
| 5b | 3.43 ± 0.09 μM (48 h)/U87 (6.06 ± 0.12/CDDP) | 9.16 ± 0.40 μM (48 h)/WI-38 (77.25 ± 7.28/CDDP) | Gupta et al., 2017 |
| 5c | 3.73 ± 0.02 μM (48 h)/U87 (6.06 ± 0.12/CDDP) | 8.01 ± 0.19 μM (48 h)/WI-38 (77.25 ± 7.28/CDDP) | Gupta et al., 2017 |
| 5d | 6.39 ± 0.28 μM (48 h)/U87 (6.06 ± 0.12/CDDP) | 15.54 ± 0.22 μM (48 h)/WI-38 (77.25 ± 7.28/CDDP) | Gupta et al., 2017 |
Cell types given in bold are normal non-cancerous cells.
*
Irradiation by light (400–700 nm, 50 mW/cm2) for 5 min after 12 h incubation followed by12 h incubation.