Table 4.
Diagnostic accuracy of preoperative ultrasound and computed tomography for metastatic lymph nodes in thyroid cancer.
| Study | Criteria | Compartment | SE (%) | SP (%) | PPV (%) | NPV (%) | AC (%) |
|---|---|---|---|---|---|---|---|
|
Author (year): Kim et al. (42) Country: South Korea Type: SR Patient: 53 N1 of 165 PTC |
US: A | CLNM | 38 | 93 | 77 | 70 | 71 |
| LLNM | 64 | 92 | 83 | 82 | 82 | ||
| CT:C | CLNM | 50 | 91 | 79 | 74 | 75 | |
| LLNM | 74 | 95 | 89 | 86 | 87 | ||
| US+CT: A,C | CLNM | 54 | 84 | 68 | 74 | 72 | |
| LLNM | 77 | 91 | 84 | 87 | 86 | ||
|
Author (year): Ahn et al. (35) Country: South Korea Type: SR Patient: 117 of 183 cervical levels |
US: A | CLNM | 55 | 69 | 77 | 44 | 60 |
| LLNM | 62 | 79 | 84 | 55 | 68 | ||
| CT: C | CLNM | 74 | 44 | 72 | 47 | 64 | |
| LLNM | 77 | 70 | 81 | 64 | 74 | ||
|
Author (year): Choi et al. (43) Country: South Korea Type: SR Patient: 119 N1 of 299 PTC |
US: A,B | CLNM | 53.2 | 79.8 | 60.8 | 74.3 | 69.9 |
| LLNM | 93.9 | 25 | 93.9 | 25 | 88.7 | ||
| CT: C | CLNM | 66.7 | 79.3 | 65.5 | 80.1 | 74.6 | |
| LLNM | 81.7 | 100 | 100 | 30.8 | 83.1 | ||
| US+CT: A,B,C | CLNM | 73 | 70.2 | 59.1 | 81.5 | 71.2 | |
| LLNM | 95.9 | 25 | 94 | 33.3 | 90.6 | ||
|
Author (year): Lee et al. (48) Country: South Korea Type: SR Patient: 121 N1 of 252 PTC |
US: A | CLNM | 23 | 97 | 81 | 72 | 73 |
| LLNM | 70 | 84 | 81 | 74 | 77 | ||
| CT: B | CLNM | 41 | 90 | 66 | 76 | 74 | |
| LLNM | 82 | 64 | 69 | 78 | 73 | ||
| US+CT: A,B | CLNM | 46 | 88 | 65 | 77 | 74 | |
| LLNM | 88 | 61 | 69 | 83 | 74 | ||
|
Author (year): Lesnik et al. (50) Country: USA Type: SP Patient: 162 PTC |
US: A,B | CLNM | 26 | 95 | 78 | 66 | N/A |
| LLNM | 79 | 87 | 80 | 86 | N/A | ||
| CT: C,D | CLNM | 50 | 94 | 85 | 74 | N/A | |
| LLNM | 79 | 83 | 76 | 86 | N/A | ||
| US+CT: A,B,C,D | CLNM | 54 | 89 | 77 | 75 | N/A | |
| LLNM | 97 | 77 | 74 | 98 | N/A |
US criteria category: A: heterogeneous inner structure, loss of fatty hilum, rounded shape, taller-than-wide shape, cystic changes, microcalcifications, and peripheral vascularity; B: Lymph node size < 1 cm; CT criteria category: C: round shape, calcification, cystic or necrotic change, heterogeneous enhancement, and strong enhancement without hilar vessel enhancement; D: Short axis >1 cm in axial plane; SR, single center retrospective; SP, single prospective; PTC, papillary thyroid carcinoma; US, ultrasound; CT, computed tomography; CLNM, central lymph node metastasis; LLNM, lateral lymph node metastasis; SE, sensitivity; SP, specificity; PPV, positive predictive value; NPV, negative predictive value; AS, accuracy; N/A, not available.