Table 6.
Tissue microRNA as predictor for aggressiveness in papillary thyroid carcinoma.
| MicroRNA | Change in APTC | ETE | LNM | DM | Target molecular | References |
|---|---|---|---|---|---|---|
| MiR-126-3p | ↓ | * | ADAM9,SLC7A5 | (136) | ||
| MiR-130b | ↓ | * | N/D | (137) | ||
| MiR-135b | ↑ | * | N/D | (138) | ||
| MiR-146a | ↑ | * | * | RARβ,PRKCE | (137, 139–142) | |
| MiR-146b | ↑ | * | * | * | KIT, SMAD4, ZNRF3,IRAK1, RARβ | (137–140, 142–148) |
| MiR-16 | ↓ | * | ITGA2 | (145) | ||
| MiR-199b-5p | ↑ | * | ** | N/D | (149) | |
| MiR-221 | ↑ | * | * | * | p27,TIMP3 | (129, 132, 137, 138, 143, 145, 150) |
| MiR-222 | ↑ | * | * | p27, PPP2R2A,TIMP3 | (129, 132, 137, 138, 143, 145, 151) | |
| MiR-2861 | ↑ | ** | N/D | (152) | ||
| MiR-30a-3p | ↓ | * | N/D | (149) | ||
| MiR-34b | ↓ | * | N/D | (137) | ||
| MiR-363-3p | ↓ | * | PIK3CA | (153) | ||
| MiR-451 | ↑ | ** | N/D | (152) | ||
| MiR-613 | ↓ | * | FN1 | (145) | ||
| MiR-622 | ↓ | * | VEGFA | (154) |
APTC, aggressive papillary thyroid carcinoma; ETE, extrathyroidal extension; LNM, lymph node metastases; DM, distant metastases; N/D, not determinated.
↑
up-regulated in aggressive PTC.
↓
down-regulated in aggressive PTC.
*
related with aggressive features,
**
Related with central and lateral neck lymph node metastases.