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Left ventricular ejection fraction < 30%
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Mitral valve stenosis, defined as valve area < 1.5 cm2, mean gradient > 6 mm Hg, or any valve deformity consistent with rheumatic valvular disease
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Aortic valve stenosis, defined as valve area ≤1.0 cm2, or mean gradient > 30 mm Hg
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Circumferential pericardial effusion > 10 mm or symptomatic pericardial effusion
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Evidence of intracardiac thrombus
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Cardiac tumor or myxoma
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Atrial septal defect that warrants closure
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Complex atheroma in the ascending aorta or aortic arch as evidenced by mobile plaque
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LAA size and shape are unsuitable for closure with a WaveCrest or Watchman device