Figure 5.

For the case where polarization directions are chosen using a minimal cell-cell contact criterion, (A) final configuration of cell sheets after 4 h of simulation time, for cell repolarization intervals τ = 1, 2, 4, 6, 8, and 10 min. Shown are plots of (B) average cell elongation shape factor index, (C) average leading-edge displacement, (D) average leading-edge roughness (LER) for each repolarization condition, and (E) average active force, calculated by averaging over the entire duration of the simulation. (B–D) Comparisons are made between the cell polarization criteria of random directions and minimal cell-cell contact. (F) Temporal evolution of the LER for each case of repolarization interval. Error bars represent the standard error. To see this figure in color, go online.