Table 1.
Brain areas visually inspected during CaMKII whole-brain screening (n = 16). Images were visually compared between blind coded groups and if a difference was suspected the area was quantified by image analysis and evaluated statistically. Three regions (Dorsolateral prefrontal cortex, Nucleus Accumbens and Tuberomammilary nucleus) showed significant treatment and/or strain difference and was together with the dorsolateral striatum included in the full sample and analysis.
| Region | Visually suspected difference after image comparison. | p-value |
Included in the second batch | ||
|---|---|---|---|---|---|
| Treatment | Strain | Interaction | |||
| Dorsolateral prefrontal cortex | Yes | .20 | .86 | .022 | Yes |
| Nucleus Accumbens (core and shell) | Yes | .82 | .38 | .027 | Yes |
| Tuberomammilary nucleus | Yes | .006 | .003 | .42 | Yes |
| Dorsolateral Striatum | N/A | – | – | – | Yes |
| Locus coeruleus | Yes | .29 | .08 | .16 | No |
| Subthalamic nucleus | Yes | .47 | .61 | .67 | No |
| Dorsal raphe nucleus | Yes | .07 | .49 | .099 | No |
| Pedunculopontine nucleus | No | – | – | – | No |
| Entopenduncular nucleus | No | – | – | – | No |
| Substantia Nigra | No | – | – | – | No |
| Orbital cortex | No | – | – | – | No |
| Thalamic nucleus (various parts) | No | – | – | – | No |
| Hippocampus | No | – | – | – | No |
| Cingulate cortex | No | – | – | – | No |