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. 2018 Dec 14;9:3085. doi: 10.3389/fmicb.2018.03085

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Copyright © 2018 Nygaard, Borgogna, Sward, Guerra, Dankoff, Collins, Pallister, Chen, Kreiswirth and Voyich.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Aspartic acid residue 51 of SaeR significantly influences the pathogenesis of murine soft-tissue infections caused by USA300. (A) Area of soft-tissue infection caused by USA300, an isogenic deletion mutant of saeR/S in USA300 (ΔsaeR/S), or USA300 with an aspartic acid to alanine substitution at SaeR residue 46 (ΔD46A), 51 (ΔD51A) or 61 (ΔD61A). (B) Representative images of soft-tissue infections from experiments in panel (A) on day 6 post-inoculation. (C) Change in the weight of mice during experiments in panel (A) between days 0 and 2 post-inoculation. (D) Inoculum of each strain given to mice in panels (A-C). Panels (A), (C), and (D) show the mean ± SEM of two independent experiments. ^∗P ≤ 0.05, ^∗∗P ≤ 0.01, ^∗∗∗P ≤ 0.001 and ^∗∗∗∗P ≤ 0.0001 relative to USA300 as determined by one-way ANOVA with Dunnett’s multiple comparison test.