Table 1.
Summary of studies developed in Latin America evaluating the role of genetic variation in pro- and anti-inflammatory mediators in PE.
| Factors | Sample size† | Key findings | Country | References |
|---|---|---|---|---|
|
ICOS (T-1564C) CTLA4 (A49G) CD28 (T17C) |
130/260 | Association with protection for PE: ICOS−1564T allele and−1564TT genotype. | Brazil | Pendeloski et al., 2011 |
| TGFB1 (G800A, C509T, T869C) | 175/253 | Association with protection for severe PE: TGFB1 869TT genotype. | Mexico | Aguilar-Duran et al., 2014 |
|
IL1R1 (rs2234650) IL12 (rs3212227) IL18 (rs187238, rs1946519) TLR2 (rs5743708) TLR4 (rs4986790) |
109/174 | No association with PE. | Brazil | Franchim et al., 2011 |
|
TNFA (G308A) IL6 (G174C) IFNG (A874T) IL10 (A1082G, C819T, C592A) TGFB1 (T869C, G915C) |
165/101a | No association with PE. | Brazil | de Lima et al., 2009 |
|
TNFA (G308A) TGFB1 (T10C, C25G) IL10 (G1082A) IL6 (G174C) IFNG (A874T) |
151/189b | Association with PE risk: IL10−1082GG genotype in white women. | Brazil | Daher et al., 2006 |
| IL1B (rs1143630) | 169/287 | Association with PE risk: IL1B rs1143630 ‘T' allele. | Brazil | Leme Galvão et al., 2016 |
| TNFA (G308A,C850T) | 105/200 | No association with PE. | Mexico | Canto-Cetina et al., 2007 |
|
IL10 (G1082A) IL6 (G174C) IL1RA (86bp-VNTR) |
411/613 | No association with PE. | Mexico | Valencia Villalvazo et al., 2012 |
|
TNFA (G308A) IL6 (G-174C) IFNG (A874T) IL10 (A1082G, C819T, C592A) TGFB1 (T869C,G915C) |
116/165c | Association with protection for PE: IL6−174C allele. | Brazil | Pinheiro et al., 2015 |
|
MBL2 allele B (rs1800450), allele C (rs1800451), allele D (rs5030737) |
157/162 | Association with PE severity: “AD” genotype, “C” and “D” alleles. | Brazil | Vianna et al., 2010 |
| CCR5 (CCR5Δ32) | 155/144 | Association with protection for PE: CCR5Δ32 allele. | Brazil | Telini et al., 2014 |
| NAMPT (rs3801266) | 389/212d | Association with GH: rs3801266 “AG” and “GG” genotypes. | Brazil | Luizon et al., 2015 |
| NAMPT (rs1319501; rs3801266) | 379/207e | Association with PE risk: rs1319501 “TC+CC” and rs3801266 “AG+GG” genotypes. | Brazil | Luizon et al., 2017 |
| LTA (+252A>G) | 30/115 | No association with PE. | Brazil | Pissetti et al., 2015 |
|
NLRP1 (rs11651270, rs12150550, rs2670660) NLRP3 (rs35829419, rs10754558) CARD8 (rs2043211, rs6509365) IL1B (rs1143634) |
286/309 | Association with risk for PE: rs12150220 (L155H) and the “rs11651270/C-rs12150220/A-rs2670660/A” haplotype. | Brazil | Pontillo et al., 2015 |
|
CYP11B2 (T344C) MR (S810L) |
100/100 | No association with PE. | Mexico | Ramírez-Salazar et al., 2011 |
| CYP11B2 (T344C) | 185/118f | No association with PE. | Brazil | de Vasconcelos et al., 2009 |
Pooled cases/controls.
Cases were grouped according severity: PE (n = 92) and eclampsia (n = 73).
Studied population was grouped according to skin color (white and non-white); white: PE (n = 56) and control (n = 92); non-white: PE (n = 95) and control (n = 97).
Cases were compared to healthy pregnant (n = 107) and non-pregnant women (n = 58).
Cases correspond to PE (n = 208) and gestational hypertension (GH) cases (n = 181).
Cases were grouped according to disorder severity and response to anti-hypertensive therapy: PE responsive (n = 60) and non-responsive (n = 145); GH responsive (n = 120) and non-responsive (n = 54).
Cases were grouped in PE (n = 70) and GH (n = 115).