Table 2.
Longitudinal percentage change in diffusion parameters from v1 to v2†
| Controls | preHD (A and B)‡ | preHD-A | preHD-B | Early HD | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | 24 | 22 | 11 | 11 | 10 | ||||||||||
| SOG | MOG | IOG | SOG | MOG | IOG | SOG | MOG | IOG | SOG | MOG | IOG | SOG | MOG | IOG | |
| MD | + 6.1 | + 3.8 | -1.1 | + 7.9 | + 5.4 | + 1.0 | + 8.4 | + 4.4 | + 0.5 | + 7.4 | + 6.2 ^ | + 1.4 | + 12.3 Φ | + 9.0 Φ | + 4.6 Φ |
| AD | + 5.6 | + 2.7 | -1.8 | + 8.0 | + 4.5 | + 0.3 | + 8.8 | + 3.7 | + 0.1 | + 7.2 | + 5.1 ^ | + 0.5 | + 12.7 Φ | + 8.3 Φ | + 3.4 Φ |
| RD | + 6.4 | + 4.5 | -0.6 | + 7.8 | + 5.9 | + 1.4 | + 8.2 | + 4.8 | + 0.8 | + 7.4 | + 6.8 ^ | + 1.9 | + 12.0 Φ | + 9.4 Φ | + 5.3 Φ |
SOG Superior Occipital Gyrus, MOG Middle Occipital Gyrus, IOG Inferior Occipital Gyrus, MD mean diffusivity, AD axial diffusivity, RD radial diffusivity
† Calculated from mixed model-based estimates of the group means for diffusion measures, corrected for age
‡ Including five subjects progressing to the early manifest stage during the two year follow-up period
Significance at p ≤ 0.017 for the omnibus F-test following Bonferroni correction: Φ significantly different from controls and preHD, ^ significantly different from preHD-A, early HD and controls. The MOG is underlined as a prime region of interest based on these results