Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct;52:8–15. doi: 10.1016/j.sbi.2018.07.002

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

High resolution structures of RNA polymerase I, II and III pre-initiation complexes (PIC). (a) Pol I PIC (pdb: 5oa1) containing Pol I, Rrn3 (sienna) and Core Factor (CF) (Rrn6: blue, Rrn7 green, Rrn11: yellow) resolved at 4.4 Å [34^•]. The path of upstream DNA is different compared to the Pol II and III PICs, and TFIIB-like Rrn7 is located further upstream from the polymerase as compared to TFIIB and Brf1. (b) Pol II PIC (pdb: 5fyw) containing Pol II, TFIIA (orange), TFIIB (green), TFIIE (pink), TFIIF (purple), and TBP (red) resolved at 3.6 Å [20]. (c) Pol III PIC (pdb: 6f40) containing Pol III and TFIIIB (Brf1, green; Bdp1, magenta; TBP, red) resolved at 3.7 Å [39^••].