Fig. 5.

The effect of anti-VEGFR2 agents on dorsal horn vascular activation. Representative low magnification images of ICAM-1 immunoreactivity in the dorsal horn (a-h). Number of ICAM-1⁺ microvessels present in the dorsal horn (i,j). Three statistical analyses were performed: 2-way analysis of variance + Dunnett’s multiple comparisons test: control vs. non-inflamed *p < 0.5, **p < 0.01, ***p < 0.001, ****p < 0.0001; anti-VEGFR2 agent vs. control (ipsi or contra): #p < 0.5, ##p < 0.01, ###p < 0.001, ####p < 0.0001 and ipsi vs. contra of respective group +p < 0.5. Day eight: n = 4; day 11: n = 4–5. Data displayed as mean ± SD.