Figure 6.

Effect of baclofen on (i) total, (ii) sedating, and (iii) stimulating components of the biphasic alcohol effects scale (BAES) in controls and AD. (A) Shows the dose response to placebo, 10 and 60 mg baclofen in controls. (B) Shows the dose response to placebo, 60 and 90 mg in AD. (C) Shows the group comparison at 60 mg baclofen (n = 12 controls and n = 8 AD) of (i) total, (ii) sedation, and (iii) stimulation components of the BAES. Data are mean ± S.E.M., *60 mg baclofen > placebo, ^#90 mg baclofen > placebo, (P < 0.05). Scale-items contributing to the sedation effects include “difficulty in concentrating,” “down,” “heavy head,” “inactive,” “sedated,” “slow thoughts,” and “sluggish.” Scale-items contributing to the stimulation effects include “elated,” “energized,” “excited” “stimulated” “talkative,” “up” and “vigorous.” Items are scored between 0 and 8.