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. 2018 Oct 24;293(50):19354–19364. doi: 10.1074/jbc.RA118.003977

Figure 7.

Figure 7.

α2δ-1 is involved in motor learning. A, mean changes show the effect of gabapentin (100 mg/kg, intraperitoneally) on the falling latency of mice during six rotarod test trials (T1–T6) over 2 consecutive days (n = 10 mice in each group). The rotarod test protocol is depicted at the top. B, mean changes show the effect of α2δ-1Tat peptide (200 pmol, 200 nl) microinjected into the dorsomedial striatum on the falling latency of mice during six rotarod test trials (T1–T6) over two consecutive days (n = 7 mice in the control peptide group; n = 8 mice in the α2δ-1Tat peptide group). C, mean changes in the falling latency in WT and Cacna2d1-knockout (KO) mice subjected to six rotarod test trials (T1–T6) over 2 consecutive days (n = 10 mice in each group). The data are means ± S.E. *, p < 0.05; **, p < 0.01 (versus respective values at T1). #, p < 0.05; ##, p < 0.01 (versus respective values in the same trial in the saline, control peptide, or WT group). Two-way ANOVA analysis followed by Tukey's post hoc test was used.