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. 2018 Nov 29;32(1):1–23. doi: 10.20524/aog.2018.0330

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Copyright: © Hellenic Society of Gastroenterology

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Suggested therapeutic algorithm for prednisolone in combination with mycophenolate mofetil (MMF) in treatment-naïve AIH patients. *In patients with risk factors (e.g., anti-LKM, anti-LC1, anti-α-actinin, anti-SLA/LP, cirrhosis at diagnosis) the tapering schedule could be applied every 3 weeks. **In relapses (↑AST, ALT ± IgG) prednisolone should be increased to the dose of initial complete response and then tapered, either by increasing the time interval twofold or by decreasing the dose of prednisolone tapering by half at the same time. ***In relapses after corticosteroid withdrawal restart prednisolone at the dose of initial complete response and taper according to **. MMF is given in two divided doses

AIH, autoimmune hepatitis; anti-LKM, anti-liver/kidney microsomal antibody; anti-LC1, antibodies against liver cytosol type-1 antigen; anti-SLA/LP, antibodies against soluble liver antigens/liver pancreas; AST, aspartate aminotransferase; ALT, alanine aminotransferase; IgG, immunoglobulin G.